Name: Anti-YARS antibody (1-300) (STJ28874)
SKU: STJ28874
Availability: InStock

Anti-YARS antibody (1-300) (STJ28874)

SKU:

STJ28874

£110.50 - £505.50

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Applications:	WB/IP/ELISA
Host:	Rabbit
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality :	Polyclonal
Isotype:	IgG
Conjugation:	Unconjugated
Concentration:	Lot specific
Purification:	Affinity purification
Dilution Range:	WB:1:500-1:2000 IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cells ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	YARS1
Gene ID:	8565
Uniprot ID:	SYYC_HUMAN
Immunogen Region:	1-300
Immunogen Sequence:	MGDAPSPEEKLHLITRNLQE VLGEEKLKEILKERELKIYW GTATTGKPHVAYFVPMSKIA DFLKAGCEVTILFADLHAYL DNMKAPWELLELRVSYYENV IKAMLESIGVPLEKLKFIKG TDYQLSKEYTLDVYRLSSVV TQHDSKKAGAEVVKQVEHPL LSGLLYPGLQALDEEYLKVD AQFGGIDQRKIFTFAEKYLP ALGYSKRVHLMNPMVPGLTG SKMSSSEEESKIDLLDRKE
Specificity:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human YARS (NP_003671.1).

Function	Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (Probable). Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity. Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1.
Protein Name	Tyrosine--Trna Ligase - Cytoplasmic Tyrosyl-Trna Synthetase Tyrrs Cleaved Into - Tyrosine--Trna Ligase - Cytoplasmic - N-Terminally Processed
Database Links	Reactome: R-HSA-379716
Cellular Localisation	Cytoplasm Nucleus Cytoplasmic In Normal Conditions Resveratrol-Binding In Response To Serum Starvation Promotes Relocalization To The Nucleus
Alternative Antibody Names	Anti-Tyrosine--Trna Ligase - Cytoplasmic antibody Anti-Tyrosyl-Trna Synthetase antibody Anti-Tyrrs Cleaved Into - Tyrosine--Trna Ligase - Cytoplasmic - N-Terminally Processed antibody Anti-YARS1 antibody Anti-YARS antibody

Information sourced from Uniprot.org

Anti-YARS antibody (1-300) (STJ28874)

General Information

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