| Host: |
Rabbit |
| Applications: |
WB/IP/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
YARS1 |
| Gene ID: |
8565 |
| Uniprot ID: |
SYYC_HUMAN |
| Immunogen Region: |
1-300 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human YARS (NP_003671.1). |
| Immunogen Sequence: |
MGDAPSPEEKLHLITRNLQE VLGEEKLKEILKERELKIYW GTATTGKPHVAYFVPMSKIA DFLKAGCEVTILFADLHAYL DNMKAPWELLELRVSYYENV IKAMLESIGVPLEKLKFIKG TDYQLSKEYTLDVYRLSSVV TQHDSKKAGAEVVKQVEHPL LSGLLYPGLQALDEEYLKVD AQFGGIDQRKIFTFAEKYLP ALGYSKRVHLMNPMVPGLTG SKMSSSEEESKIDLLDRKE |
| Function | Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (Probable). Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity. Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1. |
| Protein Name | Tyrosine--Trna Ligase - CytoplasmicTyrosyl-Trna SynthetaseTyrrs Cleaved Into - Tyrosine--Trna Ligase - Cytoplasmic - N-Terminally Processed |
| Database Links | Reactome: R-HSA-379716 |
| Cellular Localisation | CytoplasmNucleusCytoplasmic In Normal ConditionsResveratrol-Binding In Response To Serum Starvation Promotes Relocalization To The Nucleus |
| Alternative Antibody Names | Anti-Tyrosine--Trna Ligase - Cytoplasmic antibodyAnti-Tyrosyl-Trna Synthetase antibodyAnti-Tyrrs Cleaved Into - Tyrosine--Trna Ligase - Cytoplasmic - N-Terminally Processed antibodyAnti-YARS1 antibodyAnti-YARS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
