| Function | Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (Probable). Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity. Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1. |
| Protein Name | Tyrosine--Trna Ligase - CytoplasmicTyrosyl-Trna SynthetaseTyrrs Cleaved Into - Tyrosine--Trna Ligase - Cytoplasmic - N-Terminally Processed |
| Database Links | Reactome: R-HSA-379716 |
| Cellular Localisation | CytoplasmNucleusCytoplasmic In Normal ConditionsResveratrol-Binding In Response To Serum Starvation Promotes Relocalization To The Nucleus |
| Alternative Antibody Names | Anti-Tyrosine--Trna Ligase - Cytoplasmic antibodyAnti-Tyrosyl-Trna Synthetase antibodyAnti-Tyrrs Cleaved Into - Tyrosine--Trna Ligase - Cytoplasmic - N-Terminally Processed antibodyAnti-YARS1 antibodyAnti-YARS antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and HSP90AB1 knockout (KO) HeLa cells, using [KO Validated] Hsp90 Beta Rabbit polyclonal antibody (STJ119988) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/98773/382821/STJ119988_1__00628.1713151320.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and HSP90AB1 knockout (KO) HeLa cells, using [KO Validated] Hsp90 Beta Rabbit polyclonal antibody (STJ119988) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.")
