| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
XDH |
| Gene ID: |
7498 |
| Uniprot ID: |
XDH_HUMAN |
| Immunogen Region: |
1066-1084 |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 985-1084 of human Xanthine Oxidase (XDH) (NP_000370.2). |
| Immunogen Sequence: |
VDKFNKENCWKKRGLCIIPT KFGISFTVPFLNQAGALLHV YTDGSVLLTHGGTEMGQGLH TKMVQVASRALKIPTSKIYI SETSTNTVPNTSPTAASVSA DLNGQAVYAACQTILKRLEP YKKKNPSGSWEDWVTAAYMD TVSLSATGFYRTPNLGYSFE TNSGNPFHYFSYGVACSEVE IDCLTGDHKNLRTDIVMDVG SSLNPAIDIGQVEGAFVQGL GLFTLEELHYSPEGSLHTR |
| Tissue Specificity | Detected in milk (at protein level). |
| Post Translational Modifications | Subject to partial proteolysis.this alters the enzyme from the dehydrogenase form (D) to the oxidase form (O). Contains sulfhydryl groups that are easily oxidized (in vitro).this alters the enzyme from the dehydrogenase form (D) to the oxidase form (O). |
| Function | Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro). |
| Protein Name | Xanthine Dehydrogenase/Oxidase Includes - Xanthine DehydrogenaseXd - Xanthine OxidaseXoXanthine OxidoreductaseXor |
| Database Links | Reactome: R-HSA-74259Reactome: R-HSA-8851680Reactome: R-HSA-9748787 |
| Cellular Localisation | CytoplasmPeroxisomeSecreted |
| Alternative Antibody Names | Anti-Xanthine Dehydrogenase/Oxidase Includes - Xanthine Dehydrogenase antibodyAnti-Xd - Xanthine Oxidase antibodyAnti-Xo antibodyAnti-Xanthine Oxidoreductase antibodyAnti-Xor antibodyAnti-XDH antibodyAnti-XDHA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
