Anti-WEE2 antibody (151-200 aa) (STJ96269)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human WEE2 at the amino acid range 151-200
General Information
| Short Description | Rabbit polyclonal anti-Wee1-like protein kinase 2 (151-200 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:5000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | WEE2 |
| Gene ID | 494551 |
| Uniprot ID | WEE2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human WEE2 at the amino acid range 151-200 |
| Immunogen Region | 151-200 aa |
| Specificity | Wee 2 Polyclonal Antibody detects endogenous levels of Wee 2 protein. |
Additional Info
| Post Translational Modifications | Phosphorylated on serine residues. Phosphorylation leads to increase its activity. |
| Function | Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation. |
| Protein Name | Wee1-Like Protein Kinase 2Wee1-Like Protein Kinase 1bWee1b Kinase |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Wee1-Like Protein Kinase 2 antibodyAnti-Wee1-Like Protein Kinase 1b antibodyAnti-Wee1b Kinase antibodyAnti-WEE2 antibodyAnti-WEE1B antibody |
Information sourced from Uniprot.org