Host: |
Rabbit |
Applications: |
WB |
Reactivity: |
Human/Mouse |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-WD repeat-containing protein 54 (99-149 aa) is suitable for use in Western Blot research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: |
1 mg/mL |
Dilution Range: |
WB 1:500-2000 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
WDR54 |
Gene ID: |
84058 |
Uniprot ID: |
WDR54_HUMAN |
Immunogen Region: |
99-149 aa |
Specificity: |
This antibody detects endogenous levels of WDR54 at Human/Mouse |
Immunogen: |
Synthesized peptide derived from the human WDR54 at the amino acid range 99-149 |
Post Translational Modifications | Cross-linked to tightly form both dimers and trimers by TGM2. Cross-linking enhances the activation of EGF receptor-mediated signaling pathway. Cross-linking is inhibited by EGF. Ubiquitinated. EGF increases ubiquitination. |
Function | When cross-linked to form dimers and trimers, it has a regulatory effect on ERK signaling pathway activity in response to EGF stimulation. Colocalizes with the EGF receptor in WDR54-specific vesicle where it sustains the internalization and controls the degradation of the EGF receptor after EGF stimulation. |
Protein Name | Wd Repeat-Containing Protein 54 |
Cellular Localisation | VesicleAggregates In Vesicles When Cross-Linked |
Alternative Antibody Names | Anti-Wd Repeat-Containing Protein 54 antibodyAnti-WDR54 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance