| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-WBSCR22 (1-281) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BUD23 |
| Gene ID: |
114049 |
| Uniprot ID: |
BUD23_HUMAN |
| Immunogen Region: |
1-281 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-281 of human WBSCR22 (NP_059998.2). |
| Immunogen Sequence: |
MASRGRRPEHGGPPELFYDE TEARKYVRNSRMIDIQTRMA GRALELLYLPENKPCYLLDI GCGTGLSGSYLSDEGHYWVG LDISPAMLDEAVDREIEGDL LLGDMGQGIPFKPGTFDGCI SISAVQWLCNANKKSENPAK RLYCFFASLFSVLVRGSRAV LQLYPENSEQLELITTQATK AGFSGGMVVDYPNSAKAKKF YLCLFSGPSTFIPEGLSENQ DEVEPRESVFTNERFPLRM |
| Tissue Specificity | Widely expressed, with high levels in heart, skeletal muscle and kidney. Detected at high levels in bronchial brushings and in normal lung (at protein level). In fetal lung tissue, expressed in the developing bronchial lumen lining cells (at protein level). Tends to be down-regulated in lungs affected by inflammatory diseases or neoplasia (at protein level). Expressed in immune cells, including B and T lymphocytes and macrophages. |
| Post Translational Modifications | May be ubiquitinated and targeted to degradation in response to pro-inflammatory cytokine signaling. |
| Function | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA. Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors. Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements. Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro. |
| Protein Name | Probable 18s RrnaGuanine-N(7-MethyltransferaseBud Site Selection Protein 23 HomologMetastasis-Related Methyltransferase 1Williams-Beuren Syndrome Chromosomal Region 22 ProteinRrna Methyltransferase And Ribosome Maturation Factor |
| Database Links | Reactome: R-HSA-6790901Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleoplasmCytoplasmPerinuclear RegionLocalized Diffusely Throughout The Nucleus And The CytoplasmLocalizes To A Polarized Perinuclear StructureOverlapping Partially With The Golgi And LysosomesLocalization Is Not Affected By Glucocorticoid Treatment |
| Alternative Antibody Names | Anti-Probable 18s Rrna antibodyAnti-Guanine-N(7-Methyltransferase antibodyAnti-Bud Site Selection Protein 23 Homolog antibodyAnti-Metastasis-Related Methyltransferase 1 antibodyAnti-Williams-Beuren Syndrome Chromosomal Region 22 Protein antibodyAnti-Rrna Methyltransferase And Ribosome Maturation Factor antibodyAnti-BUD23 antibodyAnti-MERM1 antibodyAnti-WBSCR22 antibodyAnti-HUSSY-03 antibodyAnti-PP3381 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
