| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Wings apart-like protein homolog is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
WAPL |
| Gene ID: |
23063 |
| Uniprot ID: |
WAPL_HUMAN |
| Specificity: |
This antibody detects endogenous levels of WAPL; WAPAL at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human WAPL; WAPAL |
| Post Translational Modifications | Deubiquitinated by USP37.leading to stabilization. |
| Function | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. |
| Protein Name | Wings Apart-Like Protein HomologFriend Of Ebna2 ProteinWapl Cohesin Release Factor |
| Database Links | Reactome: R-HSA-2467813Reactome: R-HSA-2468052Reactome: R-HSA-2470946Reactome: R-HSA-2500257 |
| Cellular Localisation | Isoform 2: NucleusNucleusChromosomeCytoplasmAssociates With Chromatin Through The Cohesin Complex During InterphaseReleased In The Cytoplasm From Nuclear Envelope Breakdown Until AnaphaseIt Reaccumulates In Nucleus At Telophase |
| Alternative Antibody Names | Anti-Wings Apart-Like Protein Homolog antibodyAnti-Friend Of Ebna2 Protein antibodyAnti-Wapl Cohesin Release Factor antibodyAnti-WAPL antibodyAnti-FOE antibodyAnti-KIAA0261 antibodyAnti-WAPAL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
