| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | VPS37B |
| Gene ID: | 79720 |
| Uniprot ID: | VP37B_HUMAN |
| Immunogen Region: | 60-170 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-170 of human VPS37B (NP_078943.1). |
| Immunogen Sequence: | LLYQPQLDTLKARLTQKYQE LQVLFEAYQIKKTKLDRQSS SASLETLLALLQAEGAKIEE DTENMAEKFLDGELPLDSFI DVYQSKRKLAHMRRVKIEKL QEMVLKGQRLP |
| Tissue Specificity | Widely expressed. Expressed in macrophages and lymphocytes. |
| Function | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. |
| Protein Name | Vacuolar Protein Sorting-Associated Protein 37bHvps37bEscrt-I Complex Subunit Vps37b |
| Database Links | Reactome: R-HSA-162588Reactome: R-HSA-174490Reactome: R-HSA-917729Reactome: R-HSA-9610379Reactome: R-HSA-9615710 |
| Cellular Localisation | Late Endosome MembranePeripheral Membrane ProteinRecruited To The Endosomal Membrane In A Vps4a-Dependent Fashion |
| Alternative Antibody Names | Anti-Vacuolar Protein Sorting-Associated Protein 37b antibodyAnti-Hvps37b antibodyAnti-Escrt-I Complex Subunit Vps37b antibodyAnti-VPS37B antibody |
Information sourced from Uniprot.org