Anti-VPS13A antibody (350-600) (STJ119540)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal VPS13A (350-600) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | VPS13A |
| Gene ID | 23230 |
| Uniprot ID | VP13A_HUMAN |
| Immunogen Region | 350-600 |
| Immunogen Sequence | WSWKHIRKHRQKVKQYKELY KKKLTSKKPPGELLVSLEEL EKTLDVFNITIARQTAEVEV KKAGYKIYKEGVKDPEDNKG WFSWLWSWSEQNTNEQQPDV QPETLEEMLTPEEKALLYEA IGYSETAVDPTLLKTFEALK FFVHLKSMSIVLRENHQKPE LVDIVIEEFSTLIVQRPGAQ AIKFETKIDSFHITGLPDNS EKPRLLSSLDDAMSLFQITF EINPLDETVSQRCIIEAEP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 350-600 of human VPS13A (NP_150648.2). |
Additional Info
| Tissue Specificity | Expressed in red blood cells (at protein level). Widely expressed, with high expression in brain, heart, skeletal muscle and kidney. |
| Function | Mediates the transfer of lipids between membranes at organelle contact sites. Binds phospholipids. Required for the formation or stabilization of ER-mitochondria contact sites which enable transfer of lipids between the ER and mitochondria. Negatively regulates lipid droplet size and motility. Required for efficient lysosomal protein degradation. |
| Protein Name | Intermembrane Lipid Transfer Protein Vps13aChorea-Acanthocytosis ProteinChoreinVacuolar Protein Sorting-Associated Protein 13a |
| Database Links | |
| Cellular Localisation | Mitochondrion Outer MembranePeripheral Membrane ProteinEndoplasmic Reticulum MembraneEndosome MembraneLysosome MembraneLipid DropletGolgi ApparatusCytoplasmic VesicleSecretory VesicleNeuronal Dense Core VesicleLocalizes At Mitochondria-Endosomes And Mitochondria-Endoplasmic Reticulum Contact Sites |
| Alternative Antibody Names | Anti-Intermembrane Lipid Transfer Protein Vps13a antibodyAnti-Chorea-Acanthocytosis Protein antibodyAnti-Chorein antibodyAnti-Vacuolar Protein Sorting-Associated Protein 13a antibodyAnti-VPS13A antibodyAnti-CHAC antibodyAnti-KIAA0986 antibody |
Information sourced from Uniprot.org