Anti-VPAC2 antibody (STJA0038091)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human VIPR2
General Information
| Short Description | Rabbit monoclonal anti-VPAC2 for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | IHC 1:100-1:200 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | VIPR2 |
| Gene ID | 7434 |
| Uniprot ID | VIPR2_HUMAN |
| Immunogen | A synthesized peptide derived from human VIPR2 |
Additional Info
| Tissue Specificity | Expressed in CD4+ T-cells, but not in CD8+ T-cells. Expressed in the T-cell lines Jurkat, Peer, MOLT-4, HSB, YT and SUP-T1, but not in the T-cell lines HARRIS and HuT 78. |
| Function | G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of potency PACAP38 = VIP > PACAP27. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. May be coupled to phospholipase C. |
| Protein Name | Vasoactive Intestinal Polypeptide Receptor 2Vip-R-2Helodermin-Preferring Vip ReceptorPituitary Adenylate Cyclase-Activating Polypeptide Type Iii ReceptorPacap Type Iii ReceptorPacap-R-3Pacap-R3Vpac2 ReceptorVpac2r |
| Database Links | Reactome: R-HSA-418555Reactome: R-HSA-420092 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Vasoactive Intestinal Polypeptide Receptor 2 antibodyAnti-Vip-R-2 antibodyAnti-Helodermin-Preferring Vip Receptor antibodyAnti-Pituitary Adenylate Cyclase-Activating Polypeptide Type Iii Receptor antibodyAnti-Pacap Type Iii Receptor antibodyAnti-Pacap-R-3 antibodyAnti-Pacap-R3 antibodyAnti-Vpac2 Receptor antibodyAnti-Vpac2r antibodyAnti-VIPR2 antibodyAnti-VIP2R antibody |
Information sourced from Uniprot.org