• Western blot analysis of lysates from K562 cells, primary antibody was diluted at 1:1000, 4°C over night

Anti-VAPA antibody (34-84 aa) (STJ195181)

SKU:
STJ195181

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Vesicle-associated membrane protein-associated protein A (34-84 aa) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: VAPA
Gene ID: 9218
Uniprot ID: VAPA_HUMAN
Immunogen Region: 34-84 aa
Specificity: This antibody detects endogenous levels of VAPA at Human/Mouse/Rat
Immunogen: Synthesized peptide derived from the human VAPA at the amino acid range 34-84
Function Endoplasmic reticulum-anchored protein that mediates the formation of contact sites between the endoplasmic (ER) and late endosomes via interaction with STARD3. In addition, mediates recruitment of VAPA to plasma membrane sites through OSBPL3 binding. The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking.
Protein Name Vesicle-Associated Membrane Protein-Associated Protein A
Vamp-A
Vamp-Associated Protein A
Vap-A
33 Kda Vamp-Associated Protein
Vap-33
Database Links Reactome: R-HSA-1660661
Reactome: R-HSA-6798695
Reactome: R-HSA-9609523
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type Iv Membrane Protein
Cell Membrane
Cell Junction
Tight Junction
Nucleus Membrane
Present In The Plasma Membrane And In Intracellular Vesicles
Together With Snare Proteins
May Also Associate With The Cytoskeleton
Colocalizes With Ocln At The Tight Junction In Polarized Epithelial Cells
Alternative Antibody Names Anti-Vesicle-Associated Membrane Protein-Associated Protein A antibody
Anti-Vamp-A antibody
Anti-Vamp-Associated Protein A antibody
Anti-Vap-A antibody
Anti-33 Kda Vamp-Associated Protein antibody
Anti-Vap-33 antibody
Anti-VAPA antibody
Anti-VAP33 antibody

Information sourced from Uniprot.org

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