| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-U3 small nucleolar RNA-associated protein 4 homolog (313-363 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
UTP4 |
| Gene ID: |
84916 |
| Uniprot ID: |
UTP4_HUMAN |
| Immunogen Region: |
313-363 aa |
| Specificity: |
This antibody detects endogenous levels of CIR1A at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human CIR1A at the amino acid range 313-363 |
| Function | Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted d Involved in SSU pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase. May be a transcriptional regulator. (Microbial infection) Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5'-GGGACTTTCC-3' found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV. |
| Protein Name | U3 Small Nucleolar Rna-Associated Protein 4 HomologCirhinUtp4 Small Subunit Processome Component |
| Database Links | Reactome: R-HSA-6790901Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolusChromosomeFound Predominantly At The Fibrillar Center |
| Alternative Antibody Names | Anti-U3 Small Nucleolar Rna-Associated Protein 4 Homolog antibodyAnti-Cirhin antibodyAnti-Utp4 Small Subunit Processome Component antibodyAnti-UTP4 antibodyAnti-CIRH1A antibodyAnti-cPERP-E antibodyAnti-KIAA1988 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
