| Host: | Goat |
| Applications: | Pep-ELISA/IHC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-USP31 (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:8000.IHC: In paraffin embedded Human Cortex shows cellular body staining of neurons. Recommended concentration, 3-5µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | USP31 |
| Gene ID: | 57478 |
| Uniprot ID: | UBP31_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_065769.3 |
| Immunogen Sequence: | CKNTGDDEAERGHQ |
| Post Translational Modifications | Acetylated at Lys-1264. Acetylation decreases activity. Deacetylated by SIRT1. |
| Function | Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. May play a role in the regulation of NF-kappa-B signaling pathway by deubiquitinating TRAF2. (Microbial infection) Plays a positive role in foot-and-mouth disease and classical swine fever viral infection. Mechanistically, associates with internal ribosomal entry site (IRES) element within the 5'-untranslated region of viral genomes to promote translation of the virus-encoded polyprotein. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 31Deubiquitinating Enzyme 31Ubiquitin Thioesterase 31Ubiquitin-Specific-Processing Protease 31 |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 31 antibodyAnti-Deubiquitinating Enzyme 31 antibodyAnti-Ubiquitin Thioesterase 31 antibodyAnti-Ubiquitin-Specific-Processing Protease 31 antibodyAnti-USP31 antibodyAnti-KIAA1203 antibody |
Information sourced from Uniprot.org