| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-USH1C (264-533) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
USH1C |
| Gene ID: |
10083 |
| Uniprot ID: |
USH1C_HUMAN |
| Immunogen Region: |
264-533 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 264-533 of human USH1C (NP_001284693.1). |
| Immunogen Sequence: |
VDFSNLDHKEGRELFMTDRE RLAEARQRELQRQELLMQKR LAMESNKILQEQQEMERQRR KEIAQKAAEENERYRKEMEQ IVEEEEKFKKQWEEDWGSKE QLLLPKTITAEVHPVPLRKP KYDQGVEPELEPADDLDGGT EEQGEQDFRKYEEGFDPYSM FTPEQIMGKDVRLLRIKKEG SLDLALEGGVDSPIGKVVVS AVYERGAAERHGGIVKGDEI MAINGKIVTDYTLAEAEAA |
| Tissue Specificity | Expressed in small intestine, colon, kidney, eye and weakly in pancreas. Expressed also in vestibule of the inner ear. |
| Function | Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles. As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips. |
| Protein Name | HarmoninAntigen Ny-Co-38/Ny-Co-37Autoimmune Enteropathy-Related Antigen Aie-75Protein Pdz-73Renal Carcinoma Antigen Ny-Ren-3Usher Syndrome Type-1c Protein |
| Database Links | Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | CytoplasmCytosolCytoskeletonCell ProjectionMicrovillusColocalizes With F-ActinDetected At The Tip Of Cochlear Hair Cell StereociliaEnriched In Microvilli Of The Intestinal Brush Border |
| Alternative Antibody Names | Anti-Harmonin antibodyAnti-Antigen Ny-Co-38/Ny-Co-37 antibodyAnti-Autoimmune Enteropathy-Related Antigen Aie-75 antibodyAnti-Protein Pdz-73 antibodyAnti-Renal Carcinoma Antigen Ny-Ren-3 antibodyAnti-Usher Syndrome Type-1c Protein antibodyAnti-USH1C antibodyAnti-AIE75 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
