Anti-ULK2 antibody (Internal Region) (STJ13102590)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from the internal region of human ULK2 conjugated to immunogenic carrier protein has been used as the antigen. The peptide is homologous in rat and mouse.
General Information
| Short Description | Rabbit polyclonal anti-ULK2 (Internal Region) for use in IHC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. Use at a dilution of 1:200 to 1:2000. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | ULK2 |
| Gene ID | 9706 |
| Uniprot ID | ULK2_HUMAN |
| Immunogen | A synthetic peptide from the internal region of human ULK2 conjugated to immunogenic carrier protein has been used as the antigen. The peptide is homologous in rat and mouse. |
| Immunogen Region | Internal Region |
| Specificity | Specific for ULK2. |
Additional Info
| Function | Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR.however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. |
| Protein Name | Serine/Threonine-Protein Kinase Ulk2Unc-51-Like Kinase 2 |
| Database Links | |
| Cellular Localisation | Cytoplasmic Vesicle MembranePeripheral Membrane ProteinLocalizes To Pre-Autophagosomal Membrane |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Ulk2 antibodyAnti-Unc-51-Like Kinase 2 antibodyAnti-ULK2 antibodyAnti-KIAA0623 antibody |
Information sourced from Uniprot.org