Anti-UGCG antibody (STJ192983)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Ceramide glucosyltransferase for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | UGCG |
| Gene ID | 7357 |
| Uniprot ID | CEGT_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | CEGT Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Participates in the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway at the cytosolic surface of the Golgi. Catalyzes the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine). GlcCer is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures. Glycosphingolipids are essential components of membrane microdomains that mediate membrane trafficking and signal transduction, implicated in many fundamental cellular processes, including growth, differentiation, migration, morphogenesis, cell-to-cell and cell-to-matrix interactions. They are required for instance in the proper development and functioning of the nervous system. As an example of their role in signal transduction, they regulate the leptin receptor/LEPR in the leptin-mediated signaling pathway. They also play an important role in the establishment of the skin barrier regulating keratinocyte differentiation and the proper assembly of the cornified envelope. The biosynthesis of GSLs is also required for the proper intestinal endocytic uptake of nutritional lipids. Catalyzes the synthesis of xylosylceramide/XylCer (such as beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine) using UDP-Xyl as xylose donor. |
| Protein Name | Ceramide GlucosyltransferaseGlct-1Glucosylceramide SynthaseGcsGlycosylceramide SynthaseUdp-Glucose Ceramide GlucosyltransferaseUdp-Glucose -N-Acylsphingosine D-Glucosyltransferase |
| Database Links | Reactome: R-HSA-9840309 |
| Cellular Localisation | Golgi Apparatus MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Ceramide Glucosyltransferase antibodyAnti-Glct-1 antibodyAnti-Glucosylceramide Synthase antibodyAnti-Gcs antibodyAnti-Glycosylceramide Synthase antibodyAnti-Udp-Glucose Ceramide Glucosyltransferase antibodyAnti-Udp-Glucose -N-Acylsphingosine D-Glucosyltransferase antibodyAnti-UGCG antibody |
Information sourced from Uniprot.org