| Short Description : | Rabbit polyclonal UCHL5 (1-328) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | UCHL5 |
| Gene ID: | 51377 |
| Uniprot ID: | UCHL5_HUMAN |
| Immunogen Region: | 1-328 |
| Immunogen Sequence: | MTGNAGEWCLMESDPGVFTE LIKGFGCRGAQVEEIWSLEP ENFEKLKPVHGLIFLFKWQP GEEPAGSVVQDSRLDTIFFA KQVINNACATQAIVSVLLNC THQDVHLGETLSEFKEFSQS FDAAMKGLALSNSDVIRQVH NSFARQQMFEFDTKTSAKEE DAFHFVSYVPVNGRLYELDG LREGPIDLGACNQDDWISAV RPVIEKRIQKYSEGEIRFNL MAIVSDRKMIYEQKIAELQ |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-328 of human UCHL5 (NP_001186190.1). |
| Function | Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex.however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L5Uch-L5Ubiquitin C-Terminal Hydrolase Uch37Ubiquitin Thioesterase L5 |
| Database Links | Reactome: R-HSA-2173788Reactome: R-HSA-5689603 |
| Cellular Localisation | CytoplasmNucleusAssociates With The Proteasome 19s Subunit In The CytoplasmAssociates With The Ino80 Complex In The Nucleus |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L5 antibodyAnti-Uch-L5 antibodyAnti-Ubiquitin C-Terminal Hydrolase Uch37 antibodyAnti-Ubiquitin Thioesterase L5 antibodyAnti-UCHL5 antibodyAnti-UCH37 antibodyAnti-AD-019 antibodyAnti-CGI-70 antibody |
Information sourced from Uniprot.org
