• Western blot analysis of the lysates from K562 cells using EDD antibody.
  • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using EDD Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of lysates from A549 cells, using EDD Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using UBR5 Polyclonal Antibody. Secondary antibody was diluted at 1:20000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003, Inventbiotech, MN, USA).

Anti-UBR5 antibody (1-50 aa) (STJ96174)

SKU:
STJ96174

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-E3 ubiquitin-protein ligase UBR5 (1-50 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: UBR5
Gene ID: 51366
Uniprot ID: UBR5_HUMAN
Immunogen Region: 1-50 aa
Specificity: UBR5 Polyclonal Antibody detects endogenous levels of UBR5 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human EDD at the amino acid range 1-50
Function E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.
Protein Name E3 Ubiquitin-Protein Ligase Ubr5
E3 Ubiquitin-Protein Ligase - Hect Domain-Containing 1
Hect-Type E3 Ubiquitin Transferase Ubr5
Hyperplastic Discs Protein Homolog
Hhyd
Progestin-Induced Protein
Cellular Localisation Nucleus
Alternative Antibody Names Anti-E3 Ubiquitin-Protein Ligase Ubr5 antibody
Anti-E3 Ubiquitin-Protein Ligase - Hect Domain-Containing 1 antibody
Anti-Hect-Type E3 Ubiquitin Transferase Ubr5 antibody
Anti-Hyperplastic Discs Protein Homolog antibody
Anti-Hhyd antibody
Anti-Progestin-Induced Protein antibody
Anti-UBR5 antibody
Anti-EDD antibody
Anti-EDD1 antibody
Anti-HYD antibody
Anti-KIAA0896 antibody

Information sourced from Uniprot.org

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