| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Ubiquitin-like domain-containing CTD phosphatase 1 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | UBLCP1 |
| Gene ID: | 134510 |
| Uniprot ID: | UBCP1_HUMAN |
| Specificity: | This antibody detects endogenous levels of UBLCP1 at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human UBLCP1 |
| Function | Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. Recruited to the 19S regulatory particle of the 26S proteasome through its interaction with 19S component PSMD2/RPN1. Once recruited, dephosphorylates 19S component PSMC2/RPT1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly. Has also been reported to stimulate the proteolytic activity of the 26S proteasome. |
| Protein Name | Ubiquitin-Like Domain-Containing Ctd Phosphatase 1Nuclear Proteasome Inhibitor Ublcp1 |
| Cellular Localisation | NucleusColocalizes With Nuclear Proteasomes |
| Alternative Antibody Names | Anti-Ubiquitin-Like Domain-Containing Ctd Phosphatase 1 antibodyAnti-Nuclear Proteasome Inhibitor Ublcp1 antibodyAnti-UBLCP1 antibody |
Information sourced from Uniprot.org