Anti-UBIAD1 antibody (32-45) (STJ29955)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal UBIAD1 (32-45) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:100-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | UBIAD1 |
| Gene ID | 29914 |
| Uniprot ID | UBIA1_HUMAN |
| Immunogen Region | 32-45 |
| Immunogen Sequence | MAASQVLGEKINILSGETVK AGDRDPLGNDCPEQDRLPQR SWRQKCASYVLALRPWSFSA SLTPVALGSALAYRSHGVLD PRLLVGCAVAVLAVHGAGNL |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human UBIAD1 (NP_037451.1). |
Additional Info
| Tissue Specificity | Ubiquitously expressed. |
| Function | Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione.K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress. |
| Protein Name | Ubia Prenyltransferase Domain-Containing Protein 1Transitional Epithelial Response Protein 1 |
| Database Links | Reactome: R-HSA-6806664 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneMitochondrion MembraneCytoplasmNucleus |
| Alternative Antibody Names | Anti-Ubia Prenyltransferase Domain-Containing Protein 1 antibodyAnti-Transitional Epithelial Response Protein 1 antibodyAnti-UBIAD1 antibodyAnti-TERE1 antibody |
Information sourced from Uniprot.org