| Short Description : | Rabbit polyclonal anti-NEDD8-conjugating enzyme Ubc12 (37-87 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | UBE2M |
| Gene ID: | 9040 |
| Uniprot ID: | UBC12_HUMAN |
| Immunogen: | Synthesized peptide derived from the human UBC12 at the amino acid range 37-87 |
| Immunogen Region: | 37-87 aa |
| Specificity: | This antibody detects endogenous levels of UBC12 at Human/Mouse |
| Function | Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation. |
| Protein Name | Nedd8-Conjugating Enzyme Ubc12Nedd8 Carrier ProteinUbiquitin-Conjugating Enzyme E2 M |
| Database Links | Reactome: R-HSA-2173789Reactome: R-HSA-5607761Reactome: R-HSA-5676590Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Nedd8-Conjugating Enzyme Ubc12 antibodyAnti-Nedd8 Carrier Protein antibodyAnti-Ubiquitin-Conjugating Enzyme E2 M antibodyAnti-UBE2M antibodyAnti-UBC12 antibody |
Information sourced from Uniprot.org
