Anti-UBA1 antibody (300-600) (STJ114237)

Name: Anti-UBA1 antibody (300-600) (STJ114237)
SKU: STJ114237
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ114237

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Short Description	Rabbit polyclonal UBA1 (300-600) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	UBA1
Gene ID	7317
Uniprot ID	UBA1_HUMAN
Immunogen Region	300-600
Immunogen Sequence	KISFKSLVASLAEPDFVVTD FAKFSRPAQLHIGFQALHQF CAQHGRPPRPRNEEDAAELV ALAQAVNARALPAVQQNNLD EDLIRKLAYVAAGDLAPINA FIGGLAAQEVMKACSGKFMP IMQWLYFDALECLPEDKEVL TEDKCLQRQNRYDGQVAVFG SDLQEKLGKQKYFLVGAGAI GCELLKNFAMIGLGCGEGGE IIVTDMDTIEKSNLNRQFLF RPWDVTKLKSDTAAAAVRQ
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 300-600 of human UBA1 (NP_695012.1).

Tissue Specificity	Detected in erythrocytes (at protein level). Ubiquitous.
Post Translational Modifications	ISGylated.
Function	Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites.
Protein Name	Ubiquitin-Like Modifier-Activating Enzyme 1 Protein A1s9 Ubiquitin-Activating Enzyme E1
Database Links	Reactome: R-HSA-8866652 Reactome: R-HSA-983168
Cellular Localisation	Cytoplasm Mitochondrion Nucleus Isoform 1: Nucleus Isoform 2: Cytoplasm
Alternative Antibody Names	Anti-Ubiquitin-Like Modifier-Activating Enzyme 1 antibody Anti-Protein A1s9 antibody Anti-Ubiquitin-Activating Enzyme E1 antibody Anti-UBA1 antibody Anti-A1S9T antibody Anti-UBE1 antibody

Information sourced from Uniprot.org