| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
S7MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
UAP1 |
| Gene ID: |
6675 |
| Uniprot ID: |
UAP1_HUMAN |
| Immunogen Region: |
400-500 |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 400-500 of human UAP1 (Q16222). |
| Immunogen Sequence: |
EDEFSPLKNADSQNGKDNPT TARHALMSLHHCWVLNAGGH FIDENGSRLPAIPRSATNGK SETITADVNHNLKDANDVPI QCEISPLISYAGEGLESYVA D |
| Tissue Specificity | Widely expressed. Expressed at low level in placenta, muscle and liver. Isoform AGX1: Isoform AGX1 is more abundant in testis than isoform AGX2, while isoform AGX2 is more abundant than isoform AGX1 in somatic tissue. Isoform AGX2: Isoform AGX2 is more abundant than isoform AGX1 in somatic tissue. |
| Function | Catalyzes the last step in biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) by converting UTP and glucosamine 1-phosphate (GlcNAc-1-P) to the sugar nucleotide. Also converts UTP and galactosamine 1-phosphate (GalNAc-1-P) into uridine diphosphate-N-acetylgalactosamine (UDP-GalNAc). In addition to its role in metabolism, acts as a regulator of innate immunity in response to virus infection by mediating pyrophosphorylation of IRF3: catalyzes pyrophosphorylation of IRF3 phosphorylated at 'Ser-386' by TBK1, promoting IRF3 dimerization and activation, leading to type I interferon responses. Isoform AGX1: Isoform AGX1 has 2 to 3 times higher activity towards galactosamine 1-phosphate (GalNAc-1-P). Isoform AGX1: Isoform AGX2 has 8 times more activity towards glucosamine 1-phosphate (GlcNAc-1-P). |
| Protein Name | Udp-N-Acetylhexosamine PyrophosphorylaseAntigen XAgxProtein-Pyrophosphorylation EnzymeSperm-Associated Antigen 2Udp-N-Acetylgalactosamine PyrophosphorylaseUdp-N-Acetylglucosamine Pyrophosphorylase |
| Database Links | Reactome: R-HSA-446210 |
| Cellular Localisation | CytoplasmCytosolIn SpermatozoaLocalized To The Principal Piece Of The TailThe Neck Region Of The Head And To A Lesser ExtentThe Midpiece Of The Tail |
| Alternative Antibody Names | Anti-Udp-N-Acetylhexosamine Pyrophosphorylase antibodyAnti-Antigen X antibodyAnti-Agx antibodyAnti-Protein-Pyrophosphorylation Enzyme antibodyAnti-Sperm-Associated Antigen 2 antibodyAnti-Udp-N-Acetylgalactosamine Pyrophosphorylase antibodyAnti-Udp-N-Acetylglucosamine Pyrophosphorylase antibodyAnti-UAP1 antibodyAnti-SPAG2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
