• Western blot analysis of lysates from 293 and COS7 cells, treated with heat shock, using TYK2 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Immunofluorescence analysis of COS7 cells, using TYK2 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using TYK2 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using Tyk 2 Polyclonal Antibody diluted at 1：2000. Secondary antibody was diluted at 1:20000

Anti-TYK2 antibody (1020-1069 aa) (STJ96156)

SKU:
STJ96156

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Monkey
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Non-receptor tyrosine-protein kinase TYK2 (1020-1069 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TYK2
Gene ID: 7297
Uniprot ID: TYK2_HUMAN
Immunogen Region: 1020-1069 aa
Specificity: Tyk 2 Polyclonal Antibody detects endogenous levels of Tyk 2 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human TYK2 at the amino acid range 1020-1069
Post Translational Modifications Phosphorylated. Phosphorylation by JAK1 at Tyr-1054 and Tyr-1055 induces kinase activation.
Function Tyrosine kinase of the non-receptor type involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity. Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling. Associates with heterodimeric cytokine receptor complexes and activates STAT family members including STAT1, STAT3, STAT4 or STAT6. The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2. In response to cytokine-binding to receptors, phosphorylates and activates receptors (IFNAR1, IL12RB1, IL10RB or IL13RA1), creating docking sites for STAT members. In turn, recruited STATs are phosphorylated by TYK2 (or JAK1/JAK2 on the second receptor chain), form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes. Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling.
Protein Name Non-Receptor Tyrosine-Protein Kinase Tyk2
Database Links Reactome: R-HSA-1059683
Reactome: R-HSA-110056
Reactome: R-HSA-112411
Reactome: R-HSA-449836
Reactome: R-HSA-6783783
Reactome: R-HSA-6785807
Reactome: R-HSA-6788467
Reactome: R-HSA-8854691
Reactome: R-HSA-8984722
Reactome: R-HSA-9020591
Reactome: R-HSA-9020933
Reactome: R-HSA-9020956
Reactome: R-HSA-909733
Reactome: R-HSA-912694
Reactome: R-HSA-9674555
Reactome: R-HSA-9679191
Reactome: R-HSA-9705462
Reactome: R-HSA-9705671
Alternative Antibody Names Anti-Non-Receptor Tyrosine-Protein Kinase Tyk2 antibody
Anti-TYK2 antibody

Information sourced from Uniprot.org

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