| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TXNIP (1-166) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TXNIP |
| Gene ID: |
10628 |
| Uniprot ID: |
TXNIP_HUMAN |
| Immunogen Region: |
1-166 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-166 of human TXNIP (NP_006463.3). |
| Immunogen Sequence: |
MVMFKKIKSFEVVFNDPEKV YGSGEKVAGRVIVEVCEVTR VKAVRILACGVAKVLWMQGS QQCKQTSEYLRYEDTLLLED QPTGENEMVIMRPGNKYEYK FGFELPQGPLGTSFKGKYGC VDYWVKAFLDRPSQPTQETK KNFEVVDLVDVNTPDLMAPV SAKKEK |
| Post Translational Modifications | Ubiquitinated.undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation. |
| Function | May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). |
| Protein Name | Thioredoxin-Interacting ProteinThioredoxin-Binding Protein 2Vitamin D3 Up-Regulated Protein 1 |
| Database Links | Reactome: R-HSA-844456Reactome: R-HSA-9617629Reactome: R-HSA-9660826Reactome: R-HSA-9707564 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Thioredoxin-Interacting Protein antibodyAnti-Thioredoxin-Binding Protein 2 antibodyAnti-Vitamin D3 Up-Regulated Protein 1 antibodyAnti-TXNIP antibodyAnti-VDUP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
