| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-C10orf2 (135-335) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TWNK |
| Gene ID: |
56652 |
| Uniprot ID: |
PEO1_HUMAN |
| Immunogen Region: |
135-335 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 135-335 of human C10orf2 (NP_068602.2). |
| Immunogen Sequence: |
GAREGFLLSKAPEFEDSEEV RRIWNRAIPLWELPDQEEVQ LADTMFGLTKVTDDTLKRFS VRYLRPARSLVFPWFSPGGS GLRGLKLLEAKCQGDGVSYE ETTIPRPSAYHNLFGLPLIS RRDAEVVLTSRELDSLALNQ STGLPTLTLPRGTTCLPPAL LPYLEQFRRIVFWLGDDLRS WEAAKLFARKLNPKRCFLVR P |
| Tissue Specificity | High relative levels in skeletal muscle, testis and pancreas. Lower levels of expression in the heart, brain, placenta, lung, liver, kidney, spleen, thymus, prostate, ovary, small intestine, colon and leukocytes. Expression is coregulated with MRPL43. |
| Function | Isoform 1: Mitochondrial helicase involved in mtDNA replication and repair. Might have a role in mtDNA repair. Has DNA strand separation activity needed to form a processive replication fork for leading strand synthesis which is catalyzed by the formation of a replisome complex with POLG and mtSDB. Preferentially unwinds DNA substrates with pre-existing 5'-and 3'- single-stranded tails but is also active on a 5'- flap substrate. Can dissociate the invading strand of immobile or mobile D-loop DNA structures irrespective of the single strand polarity of the third strand. In addition to its DNA strand separation activity, also has DNA strand annealing, DNA strand-exchange and DNA branch migration activities. Isoform 2: Lack DNA unwinding and ATP hydrolysis activities. Does not bind single-stranded or double-stranded DNA. |
| Protein Name | Twinkle Mtdna HelicaseProgressive External Ophthalmoplegia 1 ProteinT7 Gp4-Like Protein With Intramitochondrial Nucleoid LocalizationT7-Like Mitochondrial Dna HelicaseTwinkle Protein - Mitochondrial |
| Database Links | Reactome: R-HSA-2151201 |
| Cellular Localisation | Mitochondrion MatrixMitochondrion NucleoidColocalizes With Mtdna In Mitochondrial NucleoidsA Nucleoproteins Complex Consisting Of A Number Of Copies Of Proteins Associated With MtdnaProbably Involved In Mtdna Maintenance And Expression |
| Alternative Antibody Names | Anti-Twinkle Mtdna Helicase antibodyAnti-Progressive External Ophthalmoplegia 1 Protein antibodyAnti-T7 Gp4-Like Protein With Intramitochondrial Nucleoid Localization antibodyAnti-T7-Like Mitochondrial Dna Helicase antibodyAnti-Twinkle Protein - Mitochondrial antibodyAnti-TWNK antibodyAnti-C10orf2 antibodyAnti-PEO1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
