Anti-TULP3 antibody (257-307 aa) (STJ195670)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human TULP3 at the amino acid range 257-307
General Information
| Short Description | Rabbit polyclonal anti-Tubby-related protein 3 (257-307 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TULP3 |
| Gene ID | 7289 |
| Uniprot ID | TULP3_HUMAN |
| Immunogen | Synthesized peptide derived from the human TULP3 at the amino acid range 257-307 |
| Immunogen Region | 257-307 aa |
| Specificity | This antibody detects endogenous levels of TULP3 at Human/Mouse |
Additional Info
| Function | Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. During adipogenesis, regulates ciliary trafficking of FFAR4 in preadipocytes. |
| Protein Name | Tubby-Related Protein 3Tubby-Like Protein 3 |
| Database Links | Reactome: R-HSA-5610787 |
| Cellular Localisation | NucleusCell MembraneCell ProjectionCiliumCytoplasmSecretedDoes Not Have A Cleavable Signal Peptide And Is Secreted By A Non-Conventional PathwayTranslocates From The Plasma Membrane To The Nucleus Upon Activation Of Guanine Nucleotide-Binding Protein G(Q) Subunit Alpha |
| Alternative Antibody Names | Anti-Tubby-Related Protein 3 antibodyAnti-Tubby-Like Protein 3 antibodyAnti-TULP3 antibodyAnti-TUBL3 antibody |
Information sourced from Uniprot.org