Anti-SND1 antibody (361-485 aa) [2D7] (STJ98437)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenPurified recombinant fragment of TudorSN (aa361-485) expressed in E. Coli.
General Information
| Short Description | Mouse monoclonal anti-Staphylococcal nuclease domain-containing protein 1 (361-485 aa) for use in WB and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 2D7 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SND1 |
| Gene ID | 27044 |
| Uniprot ID | SND1_HUMAN |
| Immunogen | Purified recombinant fragment of TudorSN (aa361-485) expressed in E. Coli. |
| Immunogen Region | 361-485 aa |
| Specificity | TudorSN Monoclonal Antibody detects endogenous levels of TudorSN protein. |
Additional Info
| Post Translational Modifications | Phosphorylated by PIM1 in vitro. |
| Function | Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition. Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for STAT5. (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). (Microbial infection) Promotes SARS-CoV-2 RNA synthesis by binding to negative-sense RNA and the viral protein nsp9. |
| Protein Name | Staphylococcal Nuclease Domain-Containing Protein 1100 Kda CoactivatorEbna2 Coactivator P100Tudor Domain-Containing Protein 11P100 Co-Activator |
| Database Links | Reactome: R-HSA-6802952 |
| Cellular Localisation | CytoplasmNucleusMelanosomeIn Il-4 Stimulated Cells Colocalizes With Stat6 In The NucleusIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-Staphylococcal Nuclease Domain-Containing Protein 1 antibodyAnti-100 Kda Coactivator antibodyAnti-Ebna2 Coactivator P100 antibodyAnti-Tudor Domain-Containing Protein 11 antibodyAnti-P100 Co-Activator antibodyAnti-SND1 antibodyAnti-TDRD11 antibody |
Information sourced from Uniprot.org