Anti-TTR antibody (68-147) [S0MR] (STJ11101990)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal TTR (68-147) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S0MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TTR |
| Gene ID | 7276 |
| Uniprot ID | TTHY_HUMAN |
| Immunogen Region | 68-147 |
| Immunogen Sequence | KTSESGELHGLTTEEEFVEG IYKVEIDTKSYWKALGISPF HEHAEVVFTANDSGPRRYTI AALLSPYSYSTTAVVTNPKE |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 68-147 of human TTR (P02766). |
Additional Info
| Tissue Specificity | Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver. |
| Post Translational Modifications | Not glycosylated under normal conditions. Following unfolding, caused for example by variant AMYLD1 'Gly-38', the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex, leading to its degradation by the ER-associated degradation (ERAD) pathway. Sulfonation of the reactive cysteine Cys-30 enhances the stability of the native conformation of TTR, avoiding misassembly of the protein leading to amyloid formation. |
| Function | Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. |
| Protein Name | TransthyretinAttrPrealbuminTbpa |
| Database Links | Reactome: R-HSA-2453902Reactome: R-HSA-3000171Reactome: R-HSA-6798695Reactome: R-HSA-975634Reactome: R-HSA-977225Reactome: R-HSA-9918449 |
| Cellular Localisation | SecretedCytoplasm |
| Alternative Antibody Names | Anti-Transthyretin antibodyAnti-Attr antibodyAnti-Prealbumin antibodyAnti-Tbpa antibodyAnti-TTR antibodyAnti-PALB antibody |
Information sourced from Uniprot.org