| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TTN (5347-5604) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TTN |
| Gene ID: |
7273 |
| Uniprot ID: |
TITIN_HUMAN |
| Immunogen Region: |
5347-5604 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 5347-5604 of human TTN (NP_596870.2). |
| Immunogen Sequence: |
LDVLPFNFVDPNMDSREGED KELKIDLEVFEMPPRFIMPI CDFKIPENSDAVFKCSVIGI PTPEVKWYKEYMCIEPDNIK YVISEEKGSHTLKIRNVCLS DSATYRCRAVNCVGEAICRG FLTMGDSEIFAVIAKKSKVT LSSLMEELVLKSNYTDSFFE FQVVEGPPRFIKGISDCYAP IGTAAYFQCLVRGSPRPTVY WYKDGKLVQGRRFTVEESGT GFHNLFITSLVKSDEGEYR |
| Tissue Specificity | Isoforms 3, 7 and 8 are expressed in cardiac muscle. Isoform 4 is expressed in vertebrate skeletal muscle. Isoform 6 is expressed in skeletal muscle (at protein level). |
| Post Translational Modifications | Autophosphorylated. |
| Function | Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. |
| Protein Name | TitinConnectinRhabdomyosarcoma Antigen Mu-Rms-40.14 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-390522 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Titin antibodyAnti-Connectin antibodyAnti-Rhabdomyosarcoma Antigen Mu-Rms-40.14 antibodyAnti-TTN antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
