| Short Description : | Rabbit polyclonal anti-Titin (161-210 aa) for use in IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC/IF/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | IHC-P 1:50-200ELISA 1:10000-20000IF 1:50-200 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TTN |
| Gene ID: | 7273 |
| Uniprot ID: | TITIN_HUMAN |
| Immunogen: | Synthetic peptide from the human protein at the amino acid range 161-210 |
| Immunogen Region: | 161-210 aa |
| Specificity: | The antibody detects endogenous TTN |
| Post Translational Modifications | Autophosphorylated. |
| Function | Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. |
| Protein Name | TitinConnectinRhabdomyosarcoma Antigen Mu-Rms-40.14 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-390522 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Titin antibodyAnti-Connectin antibodyAnti-Rhabdomyosarcoma Antigen Mu-Rms-40.14 antibodyAnti-TTN antibody |
Information sourced from Uniprot.org
