| Short Description : | Rabbit polyclonal TTF1 (806-905) antibody for use in IF, ICC and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TTF1 |
| Gene ID: | 7270 |
| Uniprot ID: | TTF1_HUMAN |
| Immunogen Region: | 806-905 |
| Immunogen Sequence: | RLKAVYVPFWQKKTFPEIID YLYETTLPLLKEKLEKMMEK KGTKIQTPAAPKQVFPFRDI FYYEDDSEGEDIEKESEGQA PCMAHACNSSTLGGQGRWII |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 806-905 of human TTF1 (NP_031370.2). |
| Function | Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. |
| Protein Name | Transcription Termination Factor 1Ttf-1Rna Polymerase I Termination FactorTranscription Termination Factor ITtf-I |
| Database Links | Reactome: R-HSA-427389Reactome: R-HSA-427413Reactome: R-HSA-5683826Reactome: R-HSA-73762Reactome: R-HSA-73863 |
| Cellular Localisation | NucleusNucleolusNucleoplasmMay Be Localized To The Nucleolus In An Npm1/B23-Dependent MannerMay Be Displaced From The Nucleolus Into The Nucleoplasm In An Cdkn2a/Arf-Dependent MannerMay Shuttle Back And Forth From Nucleoplasm To Nucleolus |
| Alternative Antibody Names | Anti-Transcription Termination Factor 1 antibodyAnti-Ttf-1 antibodyAnti-Rna Polymerase I Termination Factor antibodyAnti-Transcription Termination Factor I antibodyAnti-Ttf-I antibodyAnti-TTF1 antibody |
Information sourced from Uniprot.org
![Anti-TTF1 antibody [SM5074] (STJA0005074)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/180129/403407/STJA0005074_1__59155.1738950467.png?c=1 "Anti-TTF1 antibody [SM5074] (STJA0005074)")
