Anti-TSPAN12 antibody (221-271 aa) (STJ195283)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human TSN12 at the amino acid range 221-271
General Information
| Short Description | Rabbit polyclonal anti-Tetraspanin-12 (221-271 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TSPAN12 |
| Gene ID | 23554 |
| Uniprot ID | TSN12_HUMAN |
| Immunogen | Synthesized peptide derived from the human TSN12 at the amino acid range 221-271 |
| Immunogen Region | 221-271 aa |
| Specificity | This antibody detects endogenous levels of TSN12 at Human/Mouse/Rat |
Additional Info
| Function | Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activates the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity. |
| Protein Name | Tetraspanin-12Tspan-12Tetraspan Net-2Transmembrane 4 Superfamily Member 12 |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Tetraspanin-12 antibodyAnti-Tspan-12 antibodyAnti-Tetraspan Net-2 antibodyAnti-Transmembrane 4 Superfamily Member 12 antibodyAnti-TSPAN12 antibodyAnti-NET2 antibodyAnti-TM4SF12 antibodyAnti-UNQ774 antibodyAnti-PRO1568 antibody |
Information sourced from Uniprot.org