| Tissue Specificity | Highly expressed in heart, skeletal muscle and liver. Expressed at lower levels in lung, small intestine, kidney and spleen. |
| Function | Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs. Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure. Constitutes the major pseudouridine synthase acting on mRNAs. Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs. Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity. Acts by binding to the stem-loop structure on pri-let-7, preventing LIN28-binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation. |
| Protein Name | Pseudouridylate Synthase Trub1Trub Pseudouridine Synthase Homolog 1Trna Pseudouridine 55 Synthase Trub1Psi55 Synthase Trub1 |
| Cellular Localisation | NucleusCytoplasmCytosolCatalyzes Pseudouridylation Of Mrnas In The Nucleus |
| Alternative Antibody Names | Anti-Pseudouridylate Synthase Trub1 antibodyAnti-Trub Pseudouridine Synthase Homolog 1 antibodyAnti-Trna Pseudouridine 55 Synthase Trub1 antibodyAnti-Psi55 Synthase Trub1 antibodyAnti-TRUB1 antibodyAnti-PUS4 antibody |
Information sourced from Uniprot.org
