| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRUB1 (100-280) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRUB1 |
| Gene ID: |
142940 |
| Uniprot ID: |
TRUB1_HUMAN |
| Immunogen Region: |
100-280 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 100-280 of human TRUB1 (NP_631908.1). |
| Immunogen Sequence: |
PSPEWTKRKKQTLKIGHGGT LDSAARGVLVVGIGSGTKML TSMLSGSKRYTAIGELGKAT DTLDSTGRVTEEKPYDKITQ EDIEGILQKFTGNIMQVPPL YSALKKDGQRLSTLMKRGEV VEAKPARPVTVYSISLQKFQ PPFFTLDVECGGGFYIRSLV SDIGKELSSCANVLELTRTK Q |
| Tissue Specificity | Highly expressed in heart, skeletal muscle and liver. Expressed at lower levels in lung, small intestine, kidney and spleen. |
| Function | Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs. Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure. Constitutes the major pseudouridine synthase acting on mRNAs. Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs. Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity. Acts by binding to the stem-loop structure on pri-let-7, preventing LIN28-binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation. |
| Protein Name | Pseudouridylate Synthase Trub1Trub Pseudouridine Synthase Homolog 1Trna Pseudouridine 55 Synthase Trub1Psi55 Synthase Trub1 |
| Cellular Localisation | NucleusCytoplasmCytosolCatalyzes Pseudouridylation Of Mrnas In The Nucleus |
| Alternative Antibody Names | Anti-Pseudouridylate Synthase Trub1 antibodyAnti-Trub Pseudouridine Synthase Homolog 1 antibodyAnti-Trna Pseudouridine 55 Synthase Trub1 antibodyAnti-Psi55 Synthase Trub1 antibodyAnti-TRUB1 antibodyAnti-PUS4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
