Anti-TRPM8 antibody (STJ13100407)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from rat TRPM8 conjugated to blue carrier protein was used as the antigen. The peptide is homologous with the corresponding sequence in mouse.
General Information
| Short Description | Rabbit polyclonal anti-TRPM8 for use in IHC and WB in Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1: 1000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Trpm8 |
| Gene ID | 171382 |
| Uniprot ID | TRPM8_MOUSE |
| Immunogen | A synthetic peptide from rat TRPM8 conjugated to blue carrier protein was used as the antigen. The peptide is homologous with the corresponding sequence in mouse. |
| Specificity | Specific for TRPM8. |
Additional Info
| Post Translational Modifications | N-glycosylation is not essential for but facilitates cell surface expression, multimerization, association with lipid rafts and ion channel activity. |
| Function | Non-selective ion channel permeable to monovalent and divalent cations, including Na(+), K(+), and Ca(2+), with higher permeability for Ca(2+). Activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolality. Activated by cool temperatures (<23-28 degrees Celsius) and by chemical ligands evoking a sensation of coolness, such as menthol and icilin, therefore plays a central role in the detection of environmental cold temperatures. TRPM8 is a voltage-dependent channel.its activation by cold or chemical ligands shifts its voltage thresholds towards physiological membrane potentials, leading to the opening of the channel. In addition to its critical role in temperature sensing, regulates basal tear secretion by sensing evaporation-induced cooling and changes in osmolality. |
| Protein Name | Transient Receptor Potential Cation Channel Subfamily M Member 8Long Transient Receptor Potential Channel 6Ltrpc-6Ltrpc6Transient Receptor Potential P8Trp-P8 |
| Database Links | Reactome: R-MMU-3295583 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinMembrane RaftLipid Raft Association Modulates Trpm8 Channel Activity |
| Alternative Antibody Names | Anti-Transient Receptor Potential Cation Channel Subfamily M Member 8 antibodyAnti-Long Transient Receptor Potential Channel 6 antibodyAnti-Ltrpc-6 antibodyAnti-Ltrpc6 antibodyAnti-Transient Receptor Potential P8 antibodyAnti-Trp-P8 antibodyAnti-Trpm8 antibodyAnti-Ltrpc6 antibodyAnti-Trpp8 antibody |
Information sourced from Uniprot.org