| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-TRPC6 (10-60 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | WB. A concentration of 3-10 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | Trpc6 |
| Gene ID: | 22068 |
| Uniprot ID: | TRPC6_MOUSE |
| Immunogen Region: | 10-60 aa |
| Specificity: | Specific for TRPC6. |
| Immunogen: | A synthetic peptide from taa region 10-60 of rat TRPC6 conjugated to blue carrier protein was used as the antigen. The antigen is homologous with the corresponding sequence in mouse. |
| Post Translational Modifications | Phosphorylated by FYN, leading to an increase of TRPC6 channel activity. N-glycosylated. |
| Function | Forms a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. |
| Protein Name | Short Transient Receptor Potential Channel 6Trpc6Calcium Entry ChannelTransient Receptor Protein 6Trp-6 |
| Database Links | Reactome: R-MMU-114508Reactome: -MMU-139853Reactome: -MMU-3295583 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Short Transient Receptor Potential Channel 6 antibodyAnti-Trpc6 antibodyAnti-Calcium Entry Channel antibodyAnti-Transient Receptor Protein 6 antibodyAnti-Trp-6 antibodyAnti-Trpc6 antibodyAnti-Trp6 antibodyAnti-Trrp6 antibody |
Information sourced from Uniprot.org