| Host: |
Rabbit |
| Applications: |
WB/IHC/IF/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Activating signal cointegrator 1 (81-130 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRIP4 |
| Gene ID: |
9325 |
| Uniprot ID: |
TRIP4_HUMAN |
| Immunogen Region: |
81-130 aa |
| Specificity: |
ASC-1 Polyclonal Antibody detects endogenous levels of ASC-1 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human TRIP4 at the amino acid range 81-130 |
| Function | Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation. Also involved in androgen receptor transactivation. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. May play a role in the development of neuromuscular junction. May play a role in late myogenic differentiation. Also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. |
| Protein Name | Activating Signal Cointegrator 1Asc-1Thyroid Receptor-Interacting Protein 4Tr-Interacting Protein 4Trip-4 |
| Cellular Localisation | NucleusCytoplasmCytosolCytoskeletonMicrotubule Organizing CenterCentrosomeCytoplasmic Under Conditions Of Serum DeprivationColocalizes With Nek6 In The Centrosome |
| Alternative Antibody Names | Anti-Activating Signal Cointegrator 1 antibodyAnti-Asc-1 antibodyAnti-Thyroid Receptor-Interacting Protein 4 antibodyAnti-Tr-Interacting Protein 4 antibodyAnti-Trip-4 antibodyAnti-TRIP4 antibodyAnti-RQT4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
