| Function | E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction. Promotes also NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization independent of its E3 ligase function. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim50Ring-Type E3 Ubiquitin Transferase Trim50Tripartite Motif-Containing Protein 50 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmLocalizes Mainly Into Discrete Cytoplasmic Punctuate Structures Heterogeneous In Size And Shape Containing Polyubiquitinated Proteins |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim50 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Trim50 antibodyAnti-Tripartite Motif-Containing Protein 50 antibodyAnti-TRIM50 antibodyAnti-TRIM50A antibody |
Information sourced from Uniprot.org
