Anti-TRIM41 antibody (464-514 aa) (STJ193900)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human TRI41 at the amino acid range 464-514
General Information
| Short Description | Rabbit polyclonal anti-E3 ubiquitin-protein ligase TRIM41 (464-514 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TRIM41 |
| Gene ID | 90933 |
| Uniprot ID | TRI41_HUMAN |
| Immunogen | Synthesized peptide derived from the human TRI41 at the amino acid range 464-514 |
| Immunogen Region | 464-514 aa |
| Specificity | This antibody detects endogenous levels of TRI41 at Human/Mouse |
Additional Info
| Post Translational Modifications | Auto-ubiquitinated. |
| Function | E3 ligase that plays essential roles in innate antiviral response. Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections. Activates the innate antiviral response by catalyzing monoubiquitination of CGAS, thereby activating CGAS. Also involved in innate antiviral response by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways. Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim41Ring Finger-Interacting Protein With C KinaseRinckTripartite Motif-Containing Protein 41 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim41 antibodyAnti-Ring Finger-Interacting Protein With C Kinase antibodyAnti-Rinck antibodyAnti-Tripartite Motif-Containing Protein 41 antibodyAnti-TRIM41 antibodyAnti-RINCK antibody |
Information sourced from Uniprot.org