| Post Translational Modifications | Autoubiquitinated. |
| Function | Isoform 1: E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1. Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21. Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation. Isoform 2: Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21. Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation. Negatively regulates the canonical NF-kappa-B signaling pathway via stabilization of CACTIN in an ubiquitination-independent manner. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim39Ring Finger Protein 23Ring-Type E3 Ubiquitin Transferase Trim39Testis-Abundant Finger ProteinTripartite Motif-Containing Protein 39 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Isoform 1: CytoplasmCytosolMitochondrionNucleusFound Predominantly In The CytosolPartial Shift From The Cytosol To The Mitochondria When Colocalized With Moap1Colocalizes With Cdkn1a In The NucleusIsoform 2: Nucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim39 antibodyAnti-Ring Finger Protein 23 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Trim39 antibodyAnti-Testis-Abundant Finger Protein antibodyAnti-Tripartite Motif-Containing Protein 39 antibodyAnti-TRIM39 antibodyAnti-RNF23 antibodyAnti-TFP antibody |
Information sourced from Uniprot.org
