Host: |
Rabbit |
Applications: |
WB/ELISA |
Reactivity: |
Human |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
Purification: |
Affinity purification |
Concentration: |
Lot specific |
Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
TRIM38 |
Gene ID: |
10475 |
Uniprot ID: |
TRI38_HUMAN |
Immunogen Region: |
266-465 |
Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 266-465 of human TRIM38 (NP_006346.1). |
Immunogen Sequence: |
VSLELHTMCNVSKLYFDVKK MLRSHQVSVTLDPDTAHHEL ILSEDRRQVTRGYTQENQDT SSRRFTAFPCVLGCEGFTSG RRYFEVDVGEGTGWDLGVCM ENVQRGTGMKQEPQSGFWTL RLCKKKGYVALTSPPTSLHL HEQPLLVGIFLDYEAGVVSF YNGNTGCHIFTFPKASFSDT LRPYFQVYQYSPLFLPPPGD |
Tissue Specificity | Ubiquitous. |
Function | E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity. Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling. Acts as positive regulator of the cGAS-STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus. Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters. |
Protein Name | E3 Ubiquitin-Protein Ligase Trim38Ring Finger Protein 15Tripartite Motif-Containing Protein 38Zinc Finger Protein Roret |
Database Links | Reactome: R-HSA-877300 |
Cellular Localisation | Cytoplasm |
Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim38 antibodyAnti-Ring Finger Protein 15 antibodyAnti-Tripartite Motif-Containing Protein 38 antibodyAnti-Zinc Finger Protein Roret antibodyAnti-TRIM38 antibodyAnti-RNF15 antibodyAnti-RORET antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance