| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-E3 ubiquitin-protein ligase TRIM32 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRIM32 |
| Gene ID: |
22954 |
| Uniprot ID: |
TRI32_HUMAN |
| Specificity: |
This antibody detects endogenous levels of TRIM32 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human TRIM32 |
| Post Translational Modifications | Ubiquitinated. |
| Function | Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. Ubiquitinates PIAS4/PIASY and promotes its degradation in keratinocytes treated with UVB and TNF-alpha. Also acts as a regulator of autophagy by mediating formation of unanchored 'Lys-63'-linked polyubiquitin chains that activate ULK1: interaction with AMBRA1 is required for ULK1 activation. (Microbial infection) May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim3272 Kda Tat-Interacting ProteinRing-Type E3 Ubiquitin Transferase Trim32Tripartite Motif-Containing Protein 32Zinc Finger Protein Ht2a |
| Database Links | Reactome: R-HSA-3134975Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmLocalized In Cytoplasmic BodiesOften Located Around The Nucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim32 antibodyAnti-72 Kda Tat-Interacting Protein antibodyAnti-Ring-Type E3 Ubiquitin Transferase Trim32 antibodyAnti-Tripartite Motif-Containing Protein 32 antibodyAnti-Zinc Finger Protein Ht2a antibodyAnti-TRIM32 antibodyAnti-HT2A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
