Anti-TRH antibody (143-242) (STJ116682)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TRH (143-242) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TRH |
| Gene ID | 7200 |
| Uniprot ID | TRH_HUMAN |
| Immunogen Region | 143-242 |
| Immunogen Sequence | WLAYAVPKRQHPGRRLADPK AQRSWEEEEEEEEREEDLMP EKRQHPGKRALGGPCGPQGA YGQAGLLLGLLDDLSRSQGA EEKRQHPGRRAAWVREPLEE |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 143-242 of human TRH (NP_009048.1). |
Additional Info
| Tissue Specificity | Hypothalamus. Expressed in the hair follicle epithelium (at protein level). |
| Function | As a component of the hypothalamic-pituitary-thyroid axis, it controls the secretion of thyroid-stimulating hormone (TSH) and is involved in thyroid hormone synthesis regulation. It also operates as modulator of hair growth. It promotes hair-shaft elongation, prolongs the hair cycle growth phase (anagen) and antagonizes its termination (catagen) by TGFB2. It stimulates proliferation and inhibits apoptosis of hair matrix keratinocytes. |
| Protein Name | Pro-Thyrotropin-Releasing HormonePro-TrhProthyroliberin Cleaved Into - Thyrotropin-Releasing HormoneTrhProtirelinTsh-Releasing FactorThyroliberinThyrotropin-Releasing FactorTrf |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Pro-Thyrotropin-Releasing Hormone antibodyAnti-Pro-Trh antibodyAnti-Prothyroliberin Cleaved Into - Thyrotropin-Releasing Hormone antibodyAnti-Trh antibodyAnti-Protirelin antibodyAnti-Tsh-Releasing Factor antibodyAnti-Thyroliberin antibodyAnti-Thyrotropin-Releasing Factor antibodyAnti-Trf antibodyAnti-TRH antibody |
Information sourced from Uniprot.org