Anti-TREM1 antibody (40-120 aa) (STJ96498)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from TREM-1 at the amino acid range 40-120
General Information
| Short Description | Rabbit polyclonal anti-Triggering receptor expressed on myeloid cells 1 (40-120 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:100-500IF ICC 1:100-500ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TREM1 |
| Gene ID | 54210 |
| Uniprot ID | TREM1_HUMAN |
| Immunogen | Synthesized peptide derived from TREM-1 at the amino acid range 40-120 |
| Immunogen Region | 40-120 aa |
| Specificity | TREM-1 Polyclonal Antibody detects endogenous levels of TREM-1 protein. |
Additional Info
| Post Translational Modifications | Glycosylated. |
| Function | Isoform 1: Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses. Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12. In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma. This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections. By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis. Isoform 2: Acts as a decoy receptor, counterbalancing TREM1 pro-inflammatory activity through the neutralization of its ligand. |
| Protein Name | Triggering Receptor Expressed On Myeloid Cells 1Trem-1Triggering Receptor Expressed On Monocytes 1Cd Antigen Cd354 |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-202733Reactome: R-HSA-2172127 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinRecruited To Lipid Rafts When ActivatedIsoform 2: Secreted |
| Alternative Antibody Names | Anti-Triggering Receptor Expressed On Myeloid Cells 1 antibodyAnti-Trem-1 antibodyAnti-Triggering Receptor Expressed On Monocytes 1 antibodyAnti-Cd Antigen Cd354 antibodyAnti-TREM1 antibody |
Information sourced from Uniprot.org