| Tissue Specificity | Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta. |
| Post Translational Modifications | Phosphorylated by MAP3K3. Ubiquitinates itself upon phosphorylation. |
| Function | E3 ubiquitin and SUMO-protein ligase that plays a role in different biological processes such as innate immunity, inflammation or apoptosis. Potentiates MAP3K3-mediated activation of JUN/AP1 and DDIT3 transcriptional regulators. Negatively regulates MYB transcriptional activity by sequestering it to the cytosol via SUMOylation. Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3. Negatively regulates RLR-mediated innate immunity by promoting 'Lys-48'-linked ubiquitination of TBK1 through its RING domain to inhibit the cellular antiviral response. Promotes 'Lys-29'-linked polyubiquitination of NEMO/IKBKG and RELA leading to targeting these two proteins to lysosomal degradative pathways, reducing the transcriptional activity of NF-kappa-B. |
| Protein Name | E3 Ubiquitin-Protein Ligase Traf7Ring Finger And Wd Repeat-Containing Protein 1Ring Finger Protein 119Ring-Type E3 Ubiquitin Transferase Traf7Tnf Receptor-Associated Factor 7 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Cytoplasmic VesicleCytoplasmNucleusColocalizes With Map3k3 To Vesicle-Like Structures Throughout The Cytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Traf7 antibodyAnti-Ring Finger And Wd Repeat-Containing Protein 1 antibodyAnti-Ring Finger Protein 119 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Traf7 antibodyAnti-Tnf Receptor-Associated Factor 7 antibodyAnti-TRAF7 antibodyAnti-RFWD1 antibodyAnti-RNF119 antibody |
Information sourced from Uniprot.org
