Anti-TPMT antibody (1-245aa) [AT2E7] (STJA0041613)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenRecombinant human TPMT (1-245aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-TPMT (1-245aa) for use in ELISA, WB, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | AT2E7 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-G affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TPMT |
| Gene ID | 7172 |
| Uniprot ID | TPMT_HUMAN |
| Accession Number | NP_000358 |
| Immunogen | Recombinant human TPMT (1-245aa) purified from E. coli |
| Immunogen Region | 1-245aa |
Additional Info
| Function | Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor. TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified. |
| Protein Name | Thiopurine S-MethyltransferaseThiopurine Methyltransferase |
| Database Links | Reactome: R-HSA-156581Reactome: R-HSA-5578995Reactome: R-HSA-9748787 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Thiopurine S-Methyltransferase antibodyAnti-Thiopurine Methyltransferase antibodyAnti-TPMT antibody |
Information sourced from Uniprot.org