Anti-TPM2 antibody (1-100) (STJ25941)

Name: Anti-TPM2 antibody (1-100) (STJ25941)
SKU: STJ25941
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ25941

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Short Description	Rabbit polyclonal TPM2 (1-100) antibody for use in WB, IHC-P, IF, ICC, IP and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/IF/ICC/IP/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 IHC-P:1:50-1:100 IF/ICC:1:50-1:100 IP:0.5 Mu g-4 Mu g antibody for 400 Mu g-600 Mu g extracts of whole cells ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specif
Formulation	PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	TPM2
Gene ID	7169
Uniprot ID	TPM2_HUMAN
Immunogen Region	1-100
Immunogen Sequence	MDAIKKKMQMLKLDKENAID RAEQAEADKKQAEDRCKQLE EEQQALQKKLKGTEDEVEKY SESVKEAQEKLEQAEKKATD AEADVASLNRRIQLVEEELD
Specificity	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TPM2 (NP_003280.2).

Tissue Specificity	Present in primary breast cancer tissue, absent from normal breast tissue.
Post Translational Modifications	Phosphorylated on Ser-61 by PIK3CG. Phosphorylation on Ser-61 is required for ADRB2 internalization.
Function	Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization.
Protein Name	Tropomyosin Beta Chain Beta-Tropomyosin Tropomyosin-2
Database Links	Reactome: R-HSA-390522 Reactome: R-HSA-445355
Cellular Localisation	Cytoplasm Cytoskeleton Associates With F-Actin Stress Fibers
Alternative Antibody Names	Anti-Tropomyosin Beta Chain antibody Anti-Beta-Tropomyosin antibody Anti-Tropomyosin-2 antibody Anti-TPM2 antibody Anti-TMSB antibody

Information sourced from Uniprot.org