Anti-TPM1 antibody (101-150 aa) (STJ99331)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human Tropomyosin Alpha at the amino acid range 101-150
General Information
| Short Description | Rabbit polyclonal anti-Tropomyosin alpha-1 chain (101-150 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:10000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TPM1 |
| Gene ID | 7168 |
| Uniprot ID | TPM1_HUMAN |
| Immunogen | Synthesized peptide derived from the human Tropomyosin Alpha at the amino acid range 101-150 |
| Immunogen Region | 101-150 aa |
| Specificity | Tropomyosin Alpha Polyclonal Antibody detects endogenous levels of Tropomyosin Alpha |
Additional Info
| Post Translational Modifications | Phosphorylated at Ser-283 by DAPK1 in response to oxidative stress and this phosphorylation enhances stress fiber formation in endothelial cells. |
| Function | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. |
| Protein Name | Tropomyosin Alpha-1 ChainAlpha-TropomyosinTropomyosin-1 |
| Database Links | Reactome: R-HSA-390522Reactome: R-HSA-445355 |
| Cellular Localisation | CytoplasmCytoskeletonAssociates With F-Actin Stress Fibers |
| Alternative Antibody Names | Anti-Tropomyosin Alpha-1 Chain antibodyAnti-Alpha-Tropomyosin antibodyAnti-Tropomyosin-1 antibodyAnti-TPM1 antibodyAnti-C15orf13 antibodyAnti-TMSA antibody |
Information sourced from Uniprot.org