Anti-TOR1A antibody (STJA0009472)

SKU:
STJA0009472

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Torsin-1A is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TOR1A
Gene ID: 1861
Uniprot ID: TOR1A_HUMAN
Specificity: This antibody detects endogenous levels of Torsin A at Human, Mouse
Immunogen: Synthesized peptide derived from human Torsin A
Post Translational Modifications N-glycosylated.
Function Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues.
Protein Name Torsin-1a
Dystonia 1 Protein
Torsin Atpase-1a
Torsin Family 1 Member A
Database Links Reactome: R-HSA-8856825
Cellular Localisation Endoplasmic Reticulum Lumen
Nucleus Membrane
Peripheral Membrane Protein
Cell Projection
Growth Cone
Cytoplasmic Vesicle Membrane
Cytoplasmic Vesicle
Secretory Vesicle
Synaptic Vesicle
Cytoplasm
Cytoskeleton
Upon Oxidative Stress
Redistributes To Protusions From The Cell Surface
Peripherally Associated With The Inner Face Of The Er Membrane
Probably Mediated By The Interaction With Tor1aip1
The Association With Nucleus Membrane Is Mediated By The Interaction With Tor1aip2
Alternative Antibody Names Anti-Torsin-1a antibody
Anti-Dystonia 1 Protein antibody
Anti-Torsin Atpase-1a antibody
Anti-Torsin Family 1 Member A antibody
Anti-TOR1A antibody
Anti-DQ2 antibody
Anti-DYT1 antibody
Anti-TA antibody
Anti-TORA antibody

Information sourced from Uniprot.org

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